ABC transporters act as gate-keepers to regulate molecule traffic going in and out of cells. Transporter proteins are located within a cell membrane and act as pumps to actively transport metabolites and compounds across a cellular membrane. The transporters we study are medically relevant as they are responsible for the development of multi-drug resistance and have been implicated in diseases such as cystic fibrosis, macular degeneration due to Stargardt’s disease, non-tension glaucoma and otitis media (middle ear infection).  Dr. Pinkett’s lab uses a combination of structural biology, biochemistry and molecular genetics to determine how the transporter proteins relate to their selective function, which will impart insight into how the function of these transporters relates to disease. 

Undergraduates work on one of two projects areas: (1) biochemical studies of the proteins that regulate the expression on ABC transporters or (2) biochemical studies of ABC transporters.  Initially, you are asked to shadow a senior lab member to get your feet wet.  Our undergraduates work on independent project after 6 months and report to the PI on a weekly basis to discuss results.

LAST UPDATED 9/20/2018